METHOD FOR DIFFERENTIAL DIAGNOSIS OF CHRONIC LYMPHOCYTIC LEUKEMIA AND B-CELL NON-HODGKIN LYMPHOMA Russian patent published in 2025 - IPC G01N33/68 G01N33/49 G01N33/577 

FIELD: medicine.

SUBSTANCE: presented group of inventions refers to medicine, namely to oncology. There are presented methods for differential diagnosis of chronic lymphocytic leukaemia (CLL) and B-cell non-Hodgkin lymphoma (NHL). Methods include taking a peripheral blood sample from a patient and counting the number of leukocytes and lymphocytes in the peripheral blood sample, assessing the proportion of the population of HLADR+ lymphocytes, CD4+ helper T cells, T-cytotoxic CD8+ lymphocytes, activated CD3+ HLADR+ T-cells, assessment of the proportion of B-lymphocytes by markers CD20+, CD22+ and CD23+ and assessment of the CD4+/CD8+ immunoregulatory index in a peripheral blood sample in different variations.

EFFECT: proposed group of inventions provides reducing the labour intensity of the procedure for differential diagnosis of CLL and NHL, increasing its accuracy, as well as increasing the probability of detecting the disease at the early stages of the disease by determining the absolute number of leukocytes and lymphocytes in peripheral blood and estimating the proportion of the population HLADR+, CD4+, CD8+, CD3+HLADR+, CD20+, CD22+ and CD23+ and immunoregulatory index CD4+ / CD8+ in peripheral blood sample.

21 cl, 2 dwg, 1 tbl, 4 ex