RECOMBINANT VIRUSES AND USE THEREOF Russian patent published in 2025 - IPC C12N15/86 A61K39/12 

FIELD: biotechnology.

SUBSTANCE: described is a recombinant Marek disease virus serotype 1 (rMDV1), suitable for expression of a recombinant nucleotide sequence, which contains a recombinant nucleotide sequence in its genome, wherein said recombinant nucleotide sequence is located in locus MDV086.6 (SORF1) of said genome, and wherein said rMDV1 preserves coding sequence SORF2 and/or US1. Disclosed is a nucleic acid molecule coding rMDV1. Expression vector and a cell for producing rMDV1 are disclosed. Described is a method of producing rMDV1 and a method of replicating rMDV1. Described is a composition for vaccination of poultry against a pathogen containing rMDV1. Also described is a kit for vaccination of poultry, which contains said composition.

EFFECT: invention extends the range of means for expression or delivery of nucleic acid molecules to animals, especially farm birds.

23 cl, 6 dwg, 2 tbl, 7 ex