COATING FOR ELECTRODE OF DEVICE AND DEVICE FOR QUANTIFYING CONTENT OF UREA IN PHYSIOLOGICAL FLUIDS Russian patent published in 2025 - IPC C12Q1/58 G01N27/06 G01N27/327 G01N33/493 H01M4/02 

FIELD: biotechnology.

SUBSTANCE: group of inventions relates to biotechnology, specifically to a coating for an electrode used in biosensor analytical devices, and designs of said devices, and can be used for quantitative assessment of content of urea in physiological fluids, in particular saliva and urine. Coating for the electrode of the device for quantitative evaluation of the content of urea in physiological fluids contains the following layers: carbon nanomaterial, polymer material based on redox-active polymer and urease enzyme, wherein the redox-active polymer used is electropolymerised polyazur, and the carbon nanomaterial is single-wall carbon nanotubes. Apparatus for quantitative evaluation of the content of urea in physiological fluids comprises a graphite-paste electrode, the surface of which is modified with a coating according to the disclosed invention, fixed by a dialysis membrane by means of a plastic ring.

EFFECT: invention is aimed at expanding the range of determined concentrations of urea in samples of physiological fluids, increasing the stability of the device for quantitative assessment of the content of urea in physiological fluids by reducing the relative standard deviation of 15 analytical signals obtained during successive measurements of the same urea concentration to 7.2%, as well as increasing the long-term stability of device to 15 days.

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