FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to mutant proteins involved in production of L-valine, and can be used to produce L-valine in Corynebacterium glutamicum. Disclosed are mutant proteins of modified small subunit of acetohydroxy acid synthase (ilvN) with amino acid sequence SEQ ID NO: 1, in which the amino acid corresponding to position 44 is replaced with alanine, and the amino acid corresponding to position 42 in the amino acid sequence of SEQ ID NO: 1 to valine.
EFFECT: invention enables to obtain modified ilvN, which increase production of L-valine in Corynebacterium glutamicum.
9 cl, 7 tbl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
MUTANT ATP-DEPENDENT PROTEASE AND METHOD OF PRODUCING L-AMINO ACID USING SAME | 2021 |
|
RU2831447C1 |
VARIANT OF ACETOHYDROXY ACID SYNTHASE, MICROORGANISM CONTAINING SAME, AND METHOD FOR PRODUCING AMINO ACID WITH 1ST BRANCHED CHAIN | 2018 |
|
RU2743964C1 |
NOVEL VERSION OF CITRATE SYNTHASE AND METHOD OF PRODUCING L-VALINE USING SAME | 2022 |
|
RU2835063C1 |
NEW VARIANT OF CITRATE SYNTHASE AND METHOD FOR OBTAINING L-AMINO ACIDS USING IT | 2022 |
|
RU2836733C1 |
MICROORGANISM HAVING ENHANCED ABILITY TO PRODUCE L-AMINO ACID WITH BRANCHED CHAIN, AND METHOD OF PRODUCING L-AMINO ACID WITH BRANCHED CHAIN USING SAME | 2021 |
|
RU2819442C1 |
MICROORGANISM HAVING ENHANCED ABILITY TO PRODUCE L-AMINO ACID WITH BRANCHED CHAIN, AND METHOD OF PRODUCING L-AMINO ACID WITH BRANCHED CHAIN USING SAME | 2021 |
|
RU2817768C2 |
MICROORGANISMS PRODUCING L-VALINE, AND METHOD OF PRODUCING L-VALINE USING SAME | 2021 |
|
RU2822660C1 |
MICROORGANISM OF CORYNEBACTERIUM GENUS THAT PRODUCES L-AMINO ACIDS, AND METHOD FOR OBTAINING L-AMINO ACIDS USING THIS MICROORGANISM | 2019 |
|
RU2754781C1 |
NEW VARIANT OF BRANCH-CHAIN AMINO ACID PERMEASE AND METHOD FOR PRODUCING L-VALINE WITH ITS USE | 2021 |
|
RU2792638C1 |
NEW OPTION OF ASPARAGINE SYNTHASE AND A METHOD FOR OBTAINING L-VALINE USING IT | 2021 |
|
RU2793442C1 |
Authors
Dates
2025-04-24—Published
2022-03-30—Filed