METHOD OF PRODUCING CARNOSIC ACID FROM GARDEN SAGE LEAVES Russian patent published in 2025 - IPC A61K36/537 A61K31/197 A61K31/198 B01D11/02 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry, namely to a method of producing carnosic acid from garden sage leaves. Method of producing carnosic acid from garden sage leaves, comprising grinding garden sage leaves to particle size of not more than 1 mm, then crushed leaves are placed in a double layer of gauze – a "reservoir" for vegetal raw materials, the "reservoir" is placed in a circulating Soxhlet extractor, and n-hexane is poured into the extraction flask in the ratio: milled sage leaves : n-hexane ~ 1:12, a Soxhlet extractor with an extraction flask and a reflux condenser is assembled and placed in a boiling water bath, garden sage leaves are extracted by recycling n-hexane at boiling temperature for 2 hours, extract of garden sage leaves is obtained, the extract is twice treated in a separating funnel with 10% sodium bicarbonate solution in a ratio equal to the volume of the obtained hexane extract, diluted hydrochloric acid is added to combined aqueous-alkaline extracts to pH=3, treated twice in a separating funnel with n-hexane in a ratio equal to the volume of water-alkali fractions, with the combined hexane extracts, the extract is evaporated under vacuum at the boiling point of n-hexane until a supersaturated solution is formed, concentrated liquid extract is dried in air, the obtained crystals are collected and subjected to vacuum drying.

EFFECT: high technological effectiveness of the method due to exclusion of the column chromatography step, high environmental friendliness of production, reduced consumption of solvent, obtaining carnosic acid with a degree of purity of 95%.

1 cl, 3 dwg