METHOD FOR QUANTITATIVE DETERMINATION OF RIVAROXABAN IN BLOOD BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY Russian patent published in 2025 - IPC G01N30/06 G01N30/74 G01N30/32 G01N30/34 G01N30/60 

Abstract RU 2839935 C1

FIELD: analytical chemistry.

SUBSTANCE: disclosed is a method for quantitative determination of rivaroxaban in blood by high-performance liquid chromatography, including the sequential addition to whole blood of a sulfanilamide solution in acetonitrile, acetonitrile and activated carbon, ultrasonic treatment, centrifugation, filtration, separation on a chromatographic column filled with silica gel with grafted aminopropyl radicals with particle size of 5 mcm, with a pre-column filled with silica gel C18 with particle size 5 mcm, wherein the mobile phase used is a mixture of acetonitrile and 0.1% aqueous solution of formic acid in ratio of 85:15 vol.% in isocratic elution mode, detection is performed with the use of a diode matrix detector at wave length 254 nm, and the blood rivaroxaban concentration is determined at retention time 1.974 min.

EFFECT: invention provides detecting rivaroxaban in whole blood by high-performance liquid chromatography with efficient separation of rivaroxaban with other possible impurities present in the sample.

1 cl, 2 dwg, 3 tbl, 2 ex

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RU 2 839 935 C1

Authors

Moiseeva Evgeniia Sergeevna

Zolotukhina Natalia Iurevna

Gurenkova Anastasiia Aleksandrovna

Dragunova Marina Aleksandrovna

Batalov Roman Efimovich

Sitkova Ekaterina Sergeevna

Dates

2025-05-14Published

2025-03-05Filed