METHOD OF CONSERVATIVE TREATMENT OF PATIENTS WITH FORMED INTESTINAL FISTULAS OF NON-TUMOUR GENESIS Russian patent published in 2025 - IPC A61M1/00 A61M27/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to surgery, and may be used for treating the patients with formed intestinal fistulas of a non-tumour origin. Level of intestinal fistula and a volume of fistula losses are determined, and the wound surface is sanitated with the use of negative pressure vacuum therapy by placing a multilayer dressing within the defect and inserting a drain tube in the dressing; the drain tube is brought to the vacuum system through a counteropening. Secondary plaster sutures are formed without a pressure bandage until the fistula is completely healed. Vacuum therapy is two-staged. At the first stage, the dressing is formed of four layers consisting of a protective drainage film, two polyurethane sponges, a polyurethane film with a layer of polyacrylate glue. At the second stage, the dressing is formed of three layers consisting of a bioprosthesis in the form of a perforated rehydrated lyophilised cell-free dermal matrix, a polyurethane sponge and a polyurethane film with a layer of polyacrylate adhesive. At the second stage, forming the dressing is preceded by injecting plasma-free platelet lysate or allogenic thrombocytes into cicatrices, soft tissues, mucosa of intestinal fistulas. At the first and second stages, the dressings are changed every 3-5 days until the wound is completely cleaned at the first stage and until granulation tissue forms on the wound surface and intestinal mucosa within the fistula.

EFFECT: method allows to level the factors preventing regeneration, to improve the regenerative effect in the tissue surrounding the defect, to reduce the number of complications, reducing the length of treatment by using certain modes of therapy with negative pressure depending on the localization of the fistula, due to the activation of reparative regeneration by tissue saturation with growth factors obtained from thrombocytes, and the protection of the neoformed tissue with an allogenic biological coating with the outcome in the non-invasive closure of the intestinal fistula.

3 cl, 5 dwg, 2 ex