FIELD: chemistry.
SUBSTANCE: present invention relates to a method of producing quinoline-substituted tetraoxazaspiroalkanes (1)
,
characterized by that 8-aminoquinoline reacts with pentaoxaspiroalkanes in the presence of a NaOH catalyst, taken in molar ratio pentaoxaspiroalkane : 8-aminoquinoline : NaOH = 10:10:(0.05-0.07), at temperature 20 °C and atmospheric pressure in a mixture of solvents consisting of petroleum ether and ethyl acetate in volume ratio of 1:1 for 4-6 hours.
EFFECT: present invention provides a novel method for selective production of quinoline-substituted tetraoxazaspiroalkanes of general formula (1).
1 cl, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING TETRAOXATHIOSPIROALKANES | 2019 |
|
RU2726798C1 |
| METHOD OF PRODUCING (1S,4R)-1-ISOPROPYL-4-METHYL-10-ARYL-7,8,12,13-TETRAOXA-10-AZASPIRO[5_7]TRIDECANES | 2019 |
|
RU2726405C1 |
| METHOD OF PRODUCING PENTAOXASPYROALKANES | 2015 |
|
RU2601315C1 |
| METHOD OF PRODUCING 10-ARYL-7,8,12,13-TETRAOXA-10-AZA-SPIRO[5,7]TRIDECANES | 2014 |
|
RU2584950C1 |
| METHOD FOR PREPARING 9-ARYL-6,7,11,12-TETRAOX-9-AZASPHIRO[4.7]DODECANES | 2017 |
|
RU2664646C1 |
| METHOD FOR PRODUCTION OF 7ʹ-ARYLSPIRO[BICYCLO[2.2.1]HEPTANE-2,3ʹ-[1,2,4,5,7]TETRAOXAZOCANES] | 2019 |
|
RU2781794C1 |
| METHOD OF PRODUCING Α,Ω-DI-(SPIRO[ADAMANTANE-2,3'-[1,2,4,5,7]TETRAOXAZOCANE]-7'-YL)ALKANES | 2019 |
|
RU2727139C1 |
| PROCESS FOR THE PREPARATION OF 11-ARYL-8,9,13,14-TETRAOXA-11-AZASPIRO[6.7]TETRADECANES | 2017 |
|
RU2664649C1 |
| METHOD FOR PRODUCTION OF 10-HALOPHENYL-7,8,12,13-TETRAOXA-10-AZASPIRO[5_7]TRIDECANES | 2015 |
|
RU2605445C1 |
| DIPHENYLTETRAOXASYLASPIROALCANES AND METHOD FOR THEIR PREPARATION | 2020 |
|
RU2751035C1 |
