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2 841 195

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(51)

IPC

G01N33/58(2006-01-01)

C12Q1/6806(2018-01-01)

C12Q1/6827(2018-01-01)

C12Q1/686(2018-01-01)

C12Q1/6876(2018-01-01)

C12Q1/6883(2018-01-01)

(21) (22)

Application

2024101679, 2024-01-24

(24)

Start date

2024-01-24

(22)

Actual filing date

2024-01-24

(45)

Published

2025-06-03

(72)

Inventor

Postnikova Mariia IgorevnaAzarova Iuliia EduardovnaAzarova Valentina AlekseevnaKlesova Elena IurevnaMikhin Vadim PetrovichPolonikov Aleksei Valerevich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniia Gosudarstvennyi Meditsinskii Universitet" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR PREDICTION OF RISK OF TYPE 2 DIABETES MELLITUS IN WOMEN WITH OBESITY BASED ON GENOTYPING rs469994 (G>A) ZNRF3 GENE POLYMORPHISM Russian patent published in 2025 - IPC G01N33/58 C12Q1/6806 C12Q1/6827 C12Q1/686 C12Q1/6876 C12Q1/6883

Abstract RU 2841195 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, specifically to medical diagnostics, and can be used to predict the risk of developing type 2 diabetes mellitus in women with obesity. Peripheral venous blood is sampled and DNA is extracted. Polymorphic variant rs469994 (G>A) of gene ZNRF3 is analysed. If observing the genotypes rs469994-G/A or rs469994-A/A, a high risk of developing type 2 diabetes mellitus is predicted. If observing the rs469994-G/G genotype, a low risk of developing type 2 diabetes mellitus is predicted.

EFFECT: method provides obtaining new criteria for evaluating risk of developing type 2 diabetes mellitus in women with obesity according to genetic polymorphism rs469994 (G>A) of gene ZNRF3.

1 cl, 1 tbl, 3 ex

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RU 2 841 195 C1

Authors

Postnikova Mariia Igorevna

Azarova Iuliia Eduardovna

Azarova Valentina Alekseevna

Klesova Elena Iurevna

Mikhin Vadim Petrovich

Polonikov Aleksei Valerevich

Dates

2025-06-03—Published

2024-01-24—Filed