BIS-(β--HYDROXYETHYL)-β--HYDROXY-β--(n-TOLYLOXYMETHYL) ETHYLAMINE MONO (n-TOLYL) AMIDE FUMARIC ACID SALT INHIBITING AGGREGATION OF THROMBOLYTES Russian patent published in 1998 - IPC

Abstract SU 1601985 A1

FIELD: medicine. SUBSTANCE: present invention concerns dicarboxylic acid monoamide salts, more particularly bis-(β--hydroxyethyl) β--hydroxy-β--(n-tolyloxymethyl)ethyl amine salt of fumaric acid. Said salt inhibits aggregation of thrombocytes. Preparation is carried out by reacting bis-β--hydroxyethyl) β--hydroxy-β--n-tolyl- oxymethyl)ethyl) amine with mono (n-tolyl) fumaric acid amide. Yield is 92.4%, mp is 121-123 C, emperical formula: β- with the same therapeutical index (TI=385) is by 1.7 times more effective as compared with well known agent as aggregation of thrombocytes decreases. EFFECT: more active compound. 1 tbl

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SU 1 601 985 A1

Authors

Syropjatov B.Ja.

Nijazov R.Kh.

Morozova T.L.

Zubritskij M.Ju.

Chervinskij A.Ju.

Kapkan L.M.

Dates

1998-09-27Published

1989-04-25Filed