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(19)

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1 839 960

(13)

(51)

IPC

A61K39/02(2006-01-01)

C12N1/20(2006-01-01)

(21) (22)

Application

3168545/13, 1987-01-19

(22)

Actual filing date

1987-01-19

(45)

Published

2006-06-20

(72)

Inventor

Kormilitsyna Marina Il'InichnaMarakusha Boris IvanovichPetrovskaja Valentina GeorgievnaMeshcherjakova Irina Sergeevna

STRAIN FRANCISELLA TULARENSIS FOR PREPARING LIVE VACCINE AGAINST TULAREMIA Russian patent published in 2006 - IPC A61K39/02 C12N1/20

Abstract SU 1839960 A1

FIELD: biotechnology, microbiology.

SUBSTANCE: invention relates to producing vaccine preparations. The attenuated strain F. tularensis of non-arctic subspecies possessing high immugenicity is obtained. The strain is obtained by selection of streptomycin-resistant mutants of tularemia microorganism, the strain B-399 A-Cole of non-arctic subspecies. The prepared strain F. tularensis B-399 A-Cole Str^r 2500/K is deposited in NIIEM named for N. F. Hamaleya at № 97. Using this strain for preparing live vaccine against tularemia virulent strains of non-arctic subspecies provides good protective effect based on its high immunogenicity.

EFFECT: improved and valuable properties of strain.

1 tbl, 2 ex

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SU 1 839 960 A1

Authors

Kormilitsyna Marina Il'Inichna

Marakusha Boris Ivanovich

Petrovskaja Valentina Georgievna

Meshcherjakova Irina Sergeevna

Dates

2006-06-20—Published

1987-01-19—Filed