FIELD: medicine, vaccines, infections.
SUBSTANCE: invention relates to creature of preparations of bacterial origin. Vaccine strain Nik-sp. F. tularensis is prepared by selection by microbiological method from pure line of bacteria of R-form of the strain 15 NIIEG Francisella tularensis. The strain represents S-form with maximal immunizing dose for laboratory animals from 1 x 104 to 1 x 108 microbial cells in subcutaneous administration and it is able to protect their against infection with Francisella tularensis subsp. tularensis 503. The strain is deposited in All-Russian collection of industrial microorganisms FGUP GosNIIGenetics at number VKPM B-9311. The strain shows low reactogenicity, high stability, possibility in using standard media and technologies in culturing, storage and preparing that allows its using as live tularemia vaccine instead the existing vaccine 15 NIIEG F. tularensis. Invention can be used in public health, medicine and veterinary science.
EFFECT: improved and valuable properties of vaccine.
2 tbl, 4 ex
| Title | Year | Author | Number |
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