METHOD OF PREPARING OF TRANSIENT METAL COMPLEXES Russian patent published in 1995 - IPC

FIELD: organometallic chemistry. SUBSTANCE: method involves the preparing of complexes of transient metals taken from the group: ^99mTe, ¹⁸⁶Re, ¹⁸⁸Re containing nitride group: M V where M - Tc, ¹⁸⁶Re, ¹⁸⁸Re. Reagent 1: compound of transient metal - pertechnetate or perrhenate of alkaline metal or ammonium. Reagent 2: the first ligand of the general formula where R₁, R₂, R₃ - are similar or different and mean phenyl which can be substituted with CN, sulfonate group, lower alkyl which can be substituted with cyano-group. Reaction conditions: reagent 1 is subjected for interaction with the first ligand-phosphine (I): where R₁, R₂, R₃ - are similar or different and mean phenyl which can be substituted with cyano-group, sulfonate group, and with the second ligand - nitrogen-containing compound taken from the compounds of the general formula (II) where R₄ - hydrogen, lower alkyl, R₅ - lower alkylthiocarbonyl, where Z - O, S; R″ - H, lower alkyl, NH₂ or Z - NH; R″ - H or COR″′ where R″′ - lower alkoxy, lower alkyl, furyl, hydroxyphenyl or compound of the formula (III) where R₄ - as indicated above; R₆ - alkylthiocarbonyl; R₇ - hydroxyphenyl, pyridyl or ammonium or alkaline metal azide and if necessary with the third ligand from the group of compounds of the formula where R₈ - R_9/ - C(CH₃)₂SH, (CH₂)₂NH₂ or halogenide - di-lower alkylphosphine ethane, or mercaptoquinoline hydrohalogenide, in aqueous solution at the molar ratio of nitrogen-containing ligand to peroxide compound = 1: 10^-9- 10^-4. Synthesized compounds are used as radiopharmaceutical products. EFFECT: improved method of preparing of complexes indicated above. 2 cl, 3 tbl