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2 031 941

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C1

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Application

4932715/13, 1991-03-14

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Actual filing date

1991-03-14

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Published

1995-03-27

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Inventor

Doroshenko E.M.Polezhaev F.I.Gavrilov A.A.Grinbaum E.B.Jukhnova L.G.Erofeeva M.K.Lonskaja N.I.Tsaritsyna I.M.Bardina E.E.Vasil'Eva R.I.Drinevskij V.P.Gudkova E.M.Danini G.V.Ivakhov I.D.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Grippa Ramn

STRAIN OF INFLUENZA VIRUS A (H1N1) FOR PREPARING OF LIVING INFLUENZA INTRANASAL VACCINE FOR ADULT AND CHILDREN Russian patent published in 1995 - IPC

Abstract RU 2031941 C1

FIELD: medicinal virology. SUBSTANCE: vaccine strain A/92/17/89 is a recombinant prepared by crossing of epidemic virus A/Leningrad/92/89 (H1N1) with cold adopted temperature-sensitive strain A/Leningrad/134/57/17 (H2N2) - attenuation donor which is harmless for adult and children. Strain A/92/17/89 is actively reproduced in developing chicken embryos at optimal temperature (32 C), difference of infectious activity indices at 32 and 40 C - 6.75 lg ЭИД 50/0.2 ml. Recombinant inherited from actual epidemic virus 2 genes encoding surface proteins (hemagglutinin and neuraminidase) and 6 genes incoding internal proteins from attenuation donor. Genome of strain A/92/17/89 contains 3 ts-mutations that are typical for attenuation donor A/Leningrad/134/57/17 (H2N2). Strain A/92/17/89 is nonreactive for adult and children (age is 3-15 years) at intranasal administration and causes 4-fold increase of antibodies in blood in 61.9% of adult after a single vaccination. Strain is involved in ГКВ at number 2251. EFFECT: increased effectiveness of influenza strain.

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RU 2 031 941 C1

Authors

Doroshenko E.M.

Polezhaev F.I.

Gavrilov A.A.

Grinbaum E.B.

Jukhnova L.G.

Erofeeva M.K.

Lonskaja N.I.

Tsaritsyna I.M.

Bardina E.E.

Vasil'Eva R.I.

Drinevskij V.P.

Gudkova E.M.

Danini G.V.

Ivakhov I.D.

Dates

1995-03-27—Published

1991-03-14—Filed

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