FIELD: pharmaceutical industry. SUBSTANCE: enantiomers of 5-hetaryl-1,3,4-thiadiazinones were separated by kinetic racemate splitting. Racemate of 5-hetaryl-1,3,4-thiadiazinone is dissolved in inert solvent or in solvent mixture, acylated with chiral acid chloroanhydride. Prepared mixture of diastereomers is treated with amine up to the complete splitting single diastereomer to enantiomers that are the base. Then splitting products were separated and remained pure diastereomer is converted to the corresponding pure enantiomer by reaction with amine. EFFECT: improved method of separation. 2 cl
Title |
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Author |
Number |
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