FIELD: organic chemistry. SUBSTANCE: products: derivatives of methylene-bis-phosphonic acid amides of the general formula (I) $$$ where $$$ - $$$ or $$$ where $$$ - hydrogen, lower alkyl; $$$ and $$$ - hydrogen or $$$-alkyl at condition that at least one of groups $$$ means hydroxyl and at least one of groups $$$ means amino-group $$$; $$$ and $$$ mean independently hydrogen or halogen, or their pharmacologically acceptable salts. Reagent 1: methylene-bis-phosphonic acid or its incomplete ester. Reagent 2: amine $$$. Process is carried out in medium of organic solvent, at the room temperature. The synthesized compounds were used medicine as chelating agents for metabolism regulation. EFFECT: improved method of synthesis. 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF METHYLENE-BIS-PHOSPHONIC ACID | 1990 |
|
RU2074860C1 |
| DERIVATIVES OF METHYLENE-BIS-PHOSPHONIC ACID ANHYDRIDE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION | 1998 |
|
RU2205833C2 |
| NEW DERIVATIVES OF BIS-PHOSPHONIC ACID AND METHOD OF THEIR SYNTHESIS | 1991 |
|
RU2079504C1 |
| METHYLENE-BIS-PHOSPHONIC ACID DERIVATIVES AND A METHOD OF THEIR SYNTHESIS | 1991 |
|
RU2086556C1 |
| METHOD OF SYNTHESIS OF METHYLENEBISPHOSPHONIC ACIDS OR THEIR SALTS | 1992 |
|
RU2041230C1 |
| BIS-PILOCARPIC ACID ESTER DERIVATIVES AND METHOD OF THEIR SYNTHESIS | 1993 |
|
RU2100352C1 |
| DERIVATIVES OF GUANIDINEALKYL-1,1-BIS-PHOSPHONIC ACID, METHOD OF THEIR SYNTHESIS, DRUG AND METHOD OF ITS SYNTHESIS | 1992 |
|
RU2124519C1 |
| NOVEL BISPHOSPHONIC ACID COMPOUND | 2017 |
|
RU2731615C2 |
| USE OF PYRIDYLBIPHOSPHONATES AS THERAPEUTIC AGENT | 1995 |
|
RU2154482C2 |
| PHARMACEUTICAL FORMULATIONS AND METHODS INCLUDING COMBINATIONS OF 2-ALKYLIDEN DERIVATIVES OF 9-NOR-VITAMIN D AND BISPHOSPHONATE | 2004 |
|
RU2326695C2 |
