FIELD: medicine, pharmacy. SUBSTANCE: composition has a complex of radionuclide 153-Sm or 166-Ho with ligand (ethylenediaminetetramethylene phosphonic acid) and bivalent metal salt that must be frozen. Composition is prepared by interaction of bivalent metal salt with a complex radionuclide - ligand followed by freezing. Other method involves addition of bivalent metal salt to ligand, medium pH correction and addition of the acidified radionuclide solution followed by freezing and thawing before the use. Composition has minimal ligand amount and does not require intravenous administration. EFFECT: enhanced effectiveness of composition. 8 cl, 10 tbl
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