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Application

97121605/13, 1997-12-26

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Actual filing date

1997-12-26

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Published

1998-12-20

(72)

Inventor

Churakov A.M.Ioffe S.L.Tartakovskij V.A.Busygina O.G.Khropov Ju.V.Severina I.S.

(73)

Holder

Institut Organicheskoj Khimii Im.N.D.Zelinskogo Ran

ACTIVATOR OF GUANYLATE CYCLASE SOLUBLE FORM Russian patent published in 1998 - IPC

Abstract RU 2123526 C1

FIELD: biochemistry, enzymology. SUBSTANCE: invention proposes the use of derivatives of benzotetrazine-1,3-dioxide of the general formula (I) given in description where R1 - H and R2 is NO2 or R1 is NO2 and R2 is H or NO2 that are used as activators of guanylate cyclase soluble form. Derivatives of benzotetrazine- -1,3-dioxide of the general formula (I) show an activating effect on guanylate cyclase soluble form and this effect is more expressed as compared with that of prototype. Invention can be used for study of mechanism of regulation of guanylate cyclase soluble form activity. EFFECT: broadened pattern of assortment of specific regulating agents. 1 ex

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RU 2 123 526 C1

Authors

Churakov A.M.

Ioffe S.L.

Tartakovskij V.A.

Busygina O.G.

Khropov Ju.V.

Severina I.S.

Dates

1998-12-20—Published

1997-12-26—Filed

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