METHOD OF PREPARING ALUMINUM DERIVATIVES OF SALICYLIC AND ACETYLSALICYLIC ACIDS Russian patent published in 1999 - IPC

FIELD: organic synthesis. SUBSTANCE: method is intended for practical preparation of pharmacopeia forms of aluminum salicylates under pharmaceutical laboratory conditions and consists in interaction of aluminum alcoholates (isopropylate and ethylate) with salicylic and acetylsalicylic acids dissolved in absolutely dry aprotic solutions. Stepped ligand substitution reaction is carried out at 90 to 100 C. Products are isolated in the form of precipitates separated by filtration. Yield of products ranges from 92 to 100%. EFFECT: enabled preparation of any stepped alkoxide-to-salicylate substitution products and corresponding basic and neutral aluminum salts. 7 ex