ARYLBENZOYLGUANIDINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel ortho-substituted arylbenzoylguanidines of the formula (I) where R¹ means A, CF₃, Hal; R² and R³ each independently means H, Hal, A, -SO_n-R⁶, -SO₂NR⁴R⁵, Ph; R⁴ means H, A, CF₃, Ph; R⁵ means H or A; R⁶ means A; A means alkyl with 1-6 C-atoms; Ph means unsubstituted or mono-, di- or tri-substituted phenyl with A, F, Cl, Br, J or CF₃; n = 1 or 2; Hal means fluorine, chlorine, bromine or iodine atom, their physiologically acceptable salts. Compounds show good cardioprotective effect and therefore are useful for treatment of patients with infarction, for infarction prophylaxis and for stenocardia treatment. Substances counteract to any pathological hypoxic and ischemic damages and can be used for treatment of patients with primary and secondary diseases. Biologically active substances are useful for prophylaxis also. Invention describes method of their synthesis and pharmaceutical composition based on compounds of the formula (I). EFFECT: new compounds indicated above, improved method of synthesis, valuable pharmacological properties. 5 cl, 1 tbl, 7 ex