FIELD: veterinary, virology. SUBSTANCE: for preparing serum guinea pigs or rabbits are used. Foot-and-mouth virus type O, strain = 1734/Primorsky/2000 for hyperimmunization is cultured in suspension culture of cells BHK-21. Obtained virus is purified, concentrated and inactivated. For hyperimmunization of animal-donors antigen from strain 0, = 1734/Primorsky/2000 with activity in PCK 1:16, not less, and adjuvant are used. Saponin, its analogues or oily adjuvants are used as adjuvant. In 10 days after hyperimmunization animal-donors are subjected for bleeding and blood serum is obtained. EFFECT: improved preparing method, enhanced activity and specificity of preparation. 4 cl, 3 tbl, 2 dwg, 2 ex
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