STABLE MALONATE-PLATINUM COMPOSITION FOR INJECTION AND METHODS OF ITS STABILIZATION Russian patent published in 1999 - IPC

Abstract RU 2142797 C1

FIELD: medicine, oncology, pharmacy. SUBSTANCE: method involves preparing solution of carboplatinum and other malonate-platinum (II) antitumor agents containing 1,1-cyclobutane dicarboxylic acid or its salts at pH 4-8 taken at stabilizing amounts. These stabilizing agents inhibit nonfavorable decolorizing and precipitate formation. These solutions can be stabilized also by blowing a carrier with air or oxygen and, optionally, by filling free space with air or oxygen. EFFECT: increased stability of solutions at prolonged storage. 15 cl, 14 tbl, 4 ex

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RU 2 142 797 C1

Authors

Mjurrej A.Kaplan

Louen Fusanti

Robert K.Perron

Skott R.Stenberg

Shiram Agkharkar

Dzhozef B.Bogardus

Dates

1999-12-20Published

1994-08-08Filed