FIELD: veterinary microbiology, biotechnology. SUBSTANCE: industrial strains of Pasteurella multicida of serotypes A, D and B are cultured in nutrient media containing Hottinger broth with addition of 10-15% cattle serum at pH 7.6-7.8 and index of amine nitrogen 200-250 mg%. Obtained bacterial mass is subjected for inactivation with aminoethylethyleneimine which is added to bacterial suspension up to concentration 0.5-4%. Mixture is incubated at 37-38 C for 12-16 h and prepared antigen is added to sucrose-gelatin medium. Then antigen is combined with oily adjuvant in the ratio 3:7, respectively. EFFECT: enhanced immunogenic activity and specific safety of vaccine. 5 cl, 4 tbl, 8 ex
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