DERIVATIVES OF OXAZOLIDINE-2-ONE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of oxazolidine-2-one of the formula (I) where X means O; Y means or ; R¹ means or ; R² and R³ each and independently each of other means H, A or benzyl-group; A means alkyl with 1-6 carbon atoms; D means amidine- -group, aminomethyl, aminohydroxyiminomethyl, 5-methyl-1,2,4-oxadiazolidine-3-yl or guanidinomethyl; "r" and "s" mean independently each of other 0, 1, 2, 3 or 4; if necessary, free amino- or amidine-groups can be protected partially or completely with group that are specific for amino-functions, and their enantiomers, diastereomers also and their physiologically acceptable salts and method of their synthesis. These compounds show the antagonistic effect with respect to adhesion receptors and can be used for preparing the pharmaceutical composition showing the effect indicated above. EFFECT: improved method of synthesis and preparing, valuable pharmacological properties. 5 cl, 1 tbl, 15 ex