DERIVATIVES OF 8-AZABICYCLO[3,2,1]OCT-2-ENE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF DRUG PREPARING, METHODS OF INHIBITION OF REUPTAKE OF MONOAMINE NEUROMEDIATING AGENT, ESPECIALLY, SEROTONIN Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel chemical compounds, namely 8-azabicyclo[3.2.1]oct-2-ene of the formula (I) or its any enantiomers or any their mixtures, or any pharmaceutically acceptable salts where R means hydrogen atom, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl; R⁴ means phenyl that can be substituted with one or more substituents taken among the group including halogen atom, CF₃, CN, alkoxyl-, cycloalkoxyl-group, alkyl, cycloalkyl, alkenyl, alkynyl, nitro-group; benzyl that can be substituted with one or more substituents taken among the group including halogen atom, CF₃, CN, alkoxyl-, cycloalkoxyl-group, alkyl, cycloalkyl, alkenyl, alkynyl, amino-group, nitro-group, heteroaryl and aryl under condition that if R is hydrogen atom then R⁴ is not phenyl, 4-fluorophenyl or 3-trifluoromethylphenyl; if R means methyl then R⁴ is not phenyl, 4-halogenphenyl, 4-methylphenyl, 2-ethylphenyl, 2,4-dimethylphenyl, 2,4,6-trimethylphenyl, 3-trifluoromethylphenyl or 4-methoxyphenyl; if R means ethyl then R⁴ is not phenyl; if R means octyl then R⁴ is not phenyl. These compounds show useful pharmaceutical properties as inhibitors of reuptake of monoamine neuromediating agents, especially, serotonin and can be used as agents inducing rapid antidepressing effect. EFFECT: new compounds indicated above, valuable pharmacological properties, enhanced effectiveness. 11 cl, 1 tbl, 4 ex