FIELD: antibiotics, pharmacy. SUBSTANCE: invention relates to derivatives of erythromycin of the general formulas (II) 
, (III) 
, (IV) 
and (V) 
where R means substituted C1-C10-alkyl, C3-alkenyl, C3-alkynyl and others (see description). Invention proposes methods of synthesis of these derivatives, pharmaceutical composition based on thereof showing antibacterial activity and method of regulation of bacterial infection in mammal by administration to him indicated pharmaceutical composition. EFFECT: improved method of synthesis and regulation, valuable medicinal properties. 31 cl, 5 tbl
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