FIELD: medicine. SUBSTANCE: method deals with producing viral antigens in vitro due to infecting mitochondria-rich, virus-rich animal organ tissue, including hepatitis B virus (HBV) and cultivating infected tissue by human virus. The method is discovered for producing proteins in vitro due to transfecting mitochondria-rich animal tissue with recombinant vector based upon HBV and cultivating transfected tissue in dynamic system for tissue cultivation. EFFECT: higher efficiency. 23 cl, 1 tbl
