NEW LIPOSOME VECTORS OF ACTIVE SUBSTANCES Russian patent published in 2003 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to liposome vectors of active substances consisting of powdery composition. The compositions comprises mainly unilamellar liposomes with external lipid phase formed by lipids of 4-th class (phospholipids) associated in necessary with substances of 2-d class, substances of 3-d class and/or substances of 5-th class (bile acid salts, derivatives of fusidic acid) and with internal aqueous core. The core is formed by mixture M of at least two different gelatinizing non-polymerizing substances G1 and G2 with temperature of phase transition "gel-sol" 37 C or above. The substance G1 is gelatinizing substance taken among gelatins and carragheenans with melting point 45 C or lower and G2 is taken among carragheenans with properties distinguishing from carragheenans for G1 and celluloses. Melting point of gelatinizing substance G2 is 45 C or above and liposomes have diameter from 20 nm to 1 mcm but preferably from 20 nm to 500 nm. The indicated composition shows particles with mean diameter from 10 mcm to 1000 mcm consisting of one or some indicated liposomes surrounded by envelope taken among group comprising dehydrated thermoreversible aqueous gel that is similar with gel of internal core, dextrins or their mixture to provide an average 10¹⁶-10¹⁸ liposomes/g of powder and at least one active substance added into either gelatinizing internal core or in external lipid phase. Invention ensures to prepare powder- like compositions eliciting required properties, in part, improved bioavailability in oral route of administration. EFFECT: improved and valuable properties of vectors. 19 cl, 9 dwg