FIELD: medicine, pharmacy. SUBSTANCE: invention relates to pharmaceutical compositions comprising positive modulator of nicotine receptor agonist and agonist of nicotine receptor wherein indicated positive modulator shows ability to enhance effectiveness of nicotine receptor agonist. Indicated composition is used for treatment of state associated with reduced transfer in nicotine receptor, in particular, in Alzheimer's disease, schizophrenia and others. Invention claims also method for identification of positive modulator of nicotine receptor agonist. Invention provides the enhancement of activity of nicotine receptor agonist. EFFECT: valuable medicinal properties of composition. 21 cl, 6 dwg, 5 ex
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