PALLADIUM-SUBSTITUTED DERIVATIVES OF BACTERIOCHLOROPHYLL AND THEIR APPLICATION Russian patent published in 2004 - IPC

FIELD: metalloorganic compounds, medicine, pharmacy.

SUBSTANCE: invention relates to palladium-substituted derivatives of bacteriochlorophyll of the formulas (I)

(I')

or (I'')

wherein A represents hydroxyl (OH), OR₁- -O-(CH₂)_n-Y, -NH-(CH₂)_n-Y, -O-(CH₂)₂-OH, -NH-(CH₂)₂-NH-BOC or -N-(CH₂-CH=CH₂)₂ wherein R₁ represents Na⁺, K⁺, (Ca²⁺)_0.5, (Mg²⁺)_0.5, Li⁺, NH+4

, ⁺NH₃-C-(CH₂OH)₃, ⁺NH₃-CH₂-(CHOH)₄-CH₂OH, ⁺NH₂-(CH₃)-CH₂-(CHOH)₄-CH₂OH or ⁺N-(C_n'H_2n+1)₄; R₂ represents hydrogen atom (H) or (C₁-C₁₂)-alkyl for compound of the formula (I'0, and R₂ represents hydrogen atom (H), hydroxyl (OH) or COOR₄ for compound of the formula (I) wherein R₄ represents (C₁-C₁₂)-alkyl or (C₃-C₁₂)-cycloalkyl; R₃ represents hydrogen atom (H) or (C₁-C₁₂)-alkyl for compound of the formula (I'), and R₃ represents hydrogen atom (H), hydroxyl (OH) or (C₁-C₁₂)-alkyl or alkoxy-group for compound of the formula (I); n = 1, 2, 3, 4, 5 or 6; Y represents -NR'₁NR'₂ or -⁺NR'₁R'₂R'₃X wherein each R'₁, R'₂ and R'₃ represent independently of one another -CH₃ or -CH₅; X represents fluorine (F), chlorine (Cl), bromine (Br) or iodine (J) atom; n' = 1, 2, 3 or 4 and wherein ^* represents asymmetric carbon atom, and --- means an ordinary saturated bond or double unsaturated bond. Invention relates to pharmaceutical composition eliciting ability for detection or treatment of tumors and comprising at least one compound of the formula (I), (I') or (I'') and to three methods for preparing compound of the formula (I).

EFFECT: improved preparing method, valuable medicinal properties of compounds.

21 cl, 5 tbl, 11 dwg, 23 ex