Show metadata Hide metadata

(19)

(11)

2 352 563

(13)

(51)

IPC

C07D215/227(2006-01-01)

A61K31/47(2006-01-01)

A61P1/06(2006-01-01)

A61P9/10(2006-01-01)

A61P25/08(2006-01-01)

A61P11/06(2006-01-01)

A61P15/00(2006-01-01)

(21) (22)

Application

2005123046/04, 2003-12-18

(24)

Start date

2003-12-18

(22)

Actual filing date

2003-12-18

(45)

Published

2009-04-20

(72)

Inventor

Vradkhala Vivekananda M.Gribkoff Valentin KalaDehsgapta BireshvarBojssard Kristofer G.

(73)

Holder

Bristol-Maers Skvibb Kompani

ATROPOISOMERS OF 3-SUBSTITUTED-4-ARYLQUINOLINE-2-ON DERIVATIVES Russian patent published in 2009 - IPC C07D215/227 A61K31/47 A61P1/06 A61P9/10 A61P25/08 A61P11/06 A61P15/00

Abstract RU 2352563 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel atropoisomers of formula , in which R and R¹ each independently represents hydrogen or methyl; R², R³ and R⁴ each independently represents hydrogen or trifluoromethyl, on condition that R², R³ and R⁴ all do not represent hydrogen; and R⁵ represents bromine, chlorine; or to its non-toxic pharmaceutically acceptable salt, solvate. Invention also relates to pharmaceutical composition, as well as to method of treatment.

EFFECT: obtaining novel biologically active compounds, possessing properties which open calcium-activated potassium channels of high conductivity.

12 cl, 6 ex, 2 tbl, 7 dwg

Similar patents RU2352563C2

Title	Year	Author	Number
DERIVATIVES OF 1,3,4-OXADIAZOLONE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT	1999	Khevavasam Pijasena Ding Min Starrett Dzhon E. Dzhr.	RU2202548C2
DERIVATIVES OF 3-SUBSTITUTED 4-ARYLQUINOLIN-2-ONE AS MODULATORS OF POTASSIUM CHANNEL	1999	Khevavasam Pijazena Starrett Dzhon E. Ml.	RU2240998C2
PHOSPHATE DERIVATIVES OF FLUOROOXINDOLES AND METHOD FOR TREATMENT BY THEIR USING	2003	Gillman Kevin V. Khevavasam Pijasena Shmits Uill'Jam D. Lopez Omar D. Starrett Dzhon E. Povensal Dehvid P.	RU2312857C2
PYRIDOPYRIMIDINONES AND USE THEREOF AS MODULATORS OF N-METHYL-D-ASPARTATE RECEPTOR	2016	Volgraf Metyu Tszyan Yu Villemur Eliziya Sellers Bendzhamin U Goshen Lu Ajtszyun	RU2717665C2
STEREOISOMERICALLY ENRICHED 3-AMINOCARBONYL BICYCLOHEPETENE PYRIMIDINE DIAMINES AND USE THEREOF	2005	Argade Ankush Singkh Radzhinder Li Khoj	RU2416604C2
CONFORMATIONALLY RESTRICTED PI3K AND MTOR INHIBITORS	2014	Tsmilyanovits Vladimir Khebajsen Pol Dzhekson Ajlin Bofis Floran Boneker Tomas Vimann Mattias	RU2669696C2
DIPHENYL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT	1997	Romin Dzheffri L. Martin Skott V. Khevavasam Piasena Minvell Nikolas A. Gribkoff Valentin K. Stehrrett Dzhon E. Dzhr.	RU2175319C2
3-SUBSTITUTED OXINDOLE DERIVATIVES AS MODULATORS OF POTASSIUM CHANNELS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT	1996	Pijasena Khevavasam Nikolas A. Minvell Valentin K. Gribkov	RU2165925C2
6-[4-(1H-IMIDAZOL-2-YL)PIPERIDIN-1-YL]PYRIMIDIN-4-AMINE DERIVATIVES AS MODULATORS OF KINASE ACTIVITY	2014	Lan Zhosi Chen Syaolin Syao Yujfan Khak Bajard R. Goutopoulos Andreas	RU2674261C2
META-AZACYCLIC AMINOBENZOIC ACID DERIVATIVES AS PAN-INTEGRIN ANTAGONISTS	2016	Ruminski Piter G. Griggs Devid V.	RU2729518C2

RU 2 352 563 C2

Authors

Vradkhala Vivekananda M.

Gribkoff Valentin Kala

Dehsgapta Bireshvar

Bojssard Kristofer G.

Dates

2009-04-20—Published

2003-12-18—Filed