FIELD: organic chemistry, steroids, pharmacy.
SUBSTANCE: invention describes unsaturated 14,15-cyclopropanoandrostanes of the general formula (I): 
wherein R1 means hydrogen atom (H), hydroxy-group (OH); R2 means hydroxy-group (OH), hydrogen atom (H); R3 means hydrogen atom (H), (C1-C10)-alkyl at α- or β-position; R4 means halogen atom (F, Cl, Br) or pseudohalogen group (azide, rhodanide), hydroxy-group (OH), perfluoroalkyl; R5 means (C1-C4)-alkyl; if double bond is at 1,2-position then R4 can mean hydrogen atom (H). Also, invention relates to a method for preparing these compounds and pharmaceutical compositions containing these compounds. Compounds of the formula (I) are compounds eliciting gestagenic and/or androgenic effect.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
11 cl, 1 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOUNDS, SET, ANDROGENIC COMPOSITION | 2000 |
|
RU2242479C2 |
| 14-SUBSTITUTED MARCFORTINES | 1994 |
|
RU2131877C1 |
| DERIVATIVES OF ESTRA-1,3,5(10)-TRIENE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2139885C1 |
| METHOD OF PRODUCING 17-(3-HYDROXYPROPYL)-17-HYDROXYSTEROIDS | 2008 |
|
RU2466137C2 |
| DERIVATIVES OF 11β-BENZALDOXIME-ESTRA-4,9-DIENE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1994 |
|
RU2137777C1 |
| 15,15-DIALKYLSTEROID COMPOUNDS AND METHOD OF PREPARATION THEREOF | 1994 |
|
RU2147306C1 |
| PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES OF ESTRA-1,3,5(10)-TRIENE | 1995 |
|
RU2179442C2 |
| BRIDGE-CONTAINING ESTRATRIENES | 1990 |
|
RU2087479C1 |
| PROGESTERONE ANTAGONISTS | 2012 |
|
RU2608521C2 |
| SULFAMATE DERIVATIVES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS | 1996 |
|
RU2159774C2 |
