FIELD: biochemistry, pharmaceutical chemistry.
SUBSTANCE: invention relates to preparing conjugate of naturally occurring or recombinant urate oxidase (uricase) bound covalently with poly-(ethylene glycol) or poly-(ethylene oxide) (both are designated as PEG) wherein in average from 4 to 10 PEG strands are conjugated with each subunit of uricase and molecular mass of PEG is about between 20 and 40 kDa. Prepared PEG-uricase conjugates are nonimmunogenic practically and retain at least 75% of uricolytic activity of nonmodified enzyme.
EFFECT: improved preparing method, valuable properties of conjugates.
22 cl, 17 dwg, 12 ex
| Title |
Year |
Author |
Number |
| PEG-URATE OXIDASE CONJUGATES, THEIR APPLICATION, METHOD OF TETRAMERIC URICASE FORM SEPARATION |
2006 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2349341C2 |
| METHOD FOR ISOLATION OF TETRA-DIMENSIONAL FORM OF URICASE AND URICASE |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2278680C2 |
| URATE OXIDASE FREE FROM UNITS FOR PREPARATION OF NONIMMUNOGENIC POLYMERIC CONJUGATES |
2001 |
- Sherman Mehrri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzan Dzh.
|
RU2352354C2 |
| URATE OXIDASE CONJUGATES, PHARMACEUTICAL COMPOSITION FOR REDUCTION IN URIC ACID LEVELS AND METHOD FOR PREPARING CONJUGATES STATED ABOVE |
2008 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermen Meri R.
|
RU2443426C2 |
| PURIFIED PREPARATION OF MAMMALIAN URICASE, METHOD FOR ITS PREPARING, PREPARATION OF ACTIVE URICASE CONJUGATE AND PHARMACEUTICAL COMPOSITION |
2001 |
- Sherman Merri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
|
RU2281954C2 |
| PURIFIED PREPARATION OF URATE OXIDASE, PURIFIED RECOMBINANT URATE OXIDASE, CONJUGATE (VERSIONS) AND PHARMACEUTICAL COMPOSITION FOR REDUCING MAMMALIAN LIQUID OR TISSUE URIC ACID, PURIFIED FRAGMENTS OF URATE OXIDASE AND METHOD FOR URATE OXIDASE PURIFICATION |
2009 |
- Villiamz, L., Dehvid
- Kelli, S'Juzehn, Dzh.
- Sajfer, Mark, Dzh., P.
- Khershfild, Majkl, S.
- Shermen, Meri, R.
|
RU2557318C9 |
| VARIANT FORMS OF URATE OXIDASE AND USE THEREOF |
2012 |
- Khartman Yakob
- Mendelovits Simona
|
RU2610680C9 |
| ALTERNATIVE FORMS OF URATE OXIDASE AND USING THEM |
2006 |
- Khartman Jakob
- Mendelovits Simona
|
RU2451074C2 |
| RECOMBINANT MAMMALIAN URICASE PROTEIN FOR CONJUNCTION WITH PEG, NUCLEIC ACID MOLECULE ENCODING THE SAME EXPRESSION VECTOR, METHODS FOR PRODUCTION ABD USES THEREOF |
1999 |
- Khershfild Majkl
- Kelli S'Juzn Dzh.
|
RU2290439C2 |
| VERSION FORM URATE-OXYDASE AND ITS USE |
2006 |
- Khartman Jakob
- Mendelovitts Simona
|
RU2435847C2 |
