FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns biopharmaceutics and PEG conjugates of natural or recombinant urate oxidase (uricase). Uricase is bound covalently to poly(ethylene glycol) or poly(ethylene oxide) (both denoted as PEG), with average of 2 to 10 PEG threads are conjugated with each uricase sub-unit, and average molecular weight of PEG is approximately between 5 kDa and 100 kDa.
EFFECT: obtaining almost non-immunogenic PEG uricase conjugates preserving at least 75% of uricolytic activity of non-modified enzyme.
44 cl, 12 ex, 17 dwg
| Title |
Year |
Author |
Number |
| METHOD FOR ISOLATION OF TETRA-DIMENSIONAL FORM OF URICASE AND URICASE |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
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1999 |
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- Sajfer Mark Dzh. P.
- Shermehn Merri R.
|
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2001 |
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- Kelli S'Juzan Dzh.
|
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2008 |
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|
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2001 |
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|
RU2281954C2 |
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2009 |
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|
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2012 |
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|
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2006 |
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|
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| RECOMBINANT MAMMALIAN URICASE PROTEIN FOR CONJUNCTION WITH PEG, NUCLEIC ACID MOLECULE ENCODING THE SAME EXPRESSION VECTOR, METHODS FOR PRODUCTION ABD USES THEREOF |
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- Khershfild Majkl
- Kelli S'Juzn Dzh.
|
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| VERSION FORM URATE-OXYDASE AND ITS USE |
2006 |
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|
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