FIELD: medicine, biochemistry, pharmaceutical industry, pharmacy.
SUBSTANCE: method involves separation of the mammalian enzyme uricase purified preparation for fractions followed by combination of fractions showing the absence of mammalian uricase aggregates exceeding octamer size based on data obtained in measurement of light scattering and ultraviolet absorption of these fractions. The prepared preparation is conjugated with poly-(ethylene glycol) or poly-(ethylene oxide) and used as a component of the pharmaceutical composition used for reducing of the concentration of uric acid in liquid or body tissue. Use of invention provides decreasing the immunogenic effect of uricase being without reducing its uricolytic effect.
EFFECT: improved preparing method, valuable medicinal and pharmaceutical properties of enzyme and pharmaceutical composition.
19 cl, 6 dwg, 6 ex
| Title |
Year |
Author |
Number |
| PURIFIED PREPARATION OF URATE OXIDASE, PURIFIED RECOMBINANT URATE OXIDASE, CONJUGATE (VERSIONS) AND PHARMACEUTICAL COMPOSITION FOR REDUCING MAMMALIAN LIQUID OR TISSUE URIC ACID, PURIFIED FRAGMENTS OF URATE OXIDASE AND METHOD FOR URATE OXIDASE PURIFICATION |
2009 |
- Villiamz, L., Dehvid
- Kelli, S'Juzehn, Dzh.
- Sajfer, Mark, Dzh., P.
- Khershfild, Majkl, S.
- Shermen, Meri, R.
|
RU2557318C9 |
| URATE OXIDASE FREE FROM UNITS FOR PREPARATION OF NONIMMUNOGENIC POLYMERIC CONJUGATES |
2001 |
- Sherman Mehrri R.
- Sehjfer Mark Dzh. P.
- Vil'Jams L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzan Dzh.
|
RU2352354C2 |
| PEG-URATE OXIDASE CONJUGATES, THEIR APPLICATION, METHOD OF TETRAMERIC URICASE FORM SEPARATION |
2006 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2349341C2 |
| METHOD FOR ISOLATION OF TETRA-DIMENSIONAL FORM OF URICASE AND URICASE |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
RU2278680C2 |
| URATE OXIDASE CONJUGATES, PHARMACEUTICAL COMPOSITION FOR REDUCTION IN URIC ACID LEVELS AND METHOD FOR PREPARING CONJUGATES STATED ABOVE |
2008 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermen Meri R.
|
RU2443426C2 |
| URICASE PEG-CONJUGATES AND THEIR APPLYING |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Merri R.
|
RU2246318C2 |
| RECOMBINANT MAMMALIAN URICASE PROTEIN FOR CONJUNCTION WITH PEG, NUCLEIC ACID MOLECULE ENCODING THE SAME EXPRESSION VECTOR, METHODS FOR PRODUCTION ABD USES THEREOF |
1999 |
- Khershfild Majkl
- Kelli S'Juzn Dzh.
|
RU2290439C2 |
| VARIANT FORMS OF URATE OXIDASE AND USE THEREOF |
2012 |
- Khartman Yakob
- Mendelovits Simona
|
RU2610680C9 |
| ALTERNATIVE FORMS OF URATE OXIDASE AND USING THEM |
2006 |
- Khartman Jakob
- Mendelovits Simona
|
RU2451074C2 |
| IMPROVED URICASE SEQUENCES AND TREATMENT METHODS |
2016 |
- Baca Manuel
- Nyborg Andrew C.
|
RU2752497C2 |
