FIELD: medicine.
SUBSTANCE: invention concerns medicine and can be used in pharmaceutical industry. The preparation of uricase of funguses, bacteria, invertebrates or plants clear of the units of uricase exceeding the sizes of octamer. The resulting uricase preparation contains not more than 2% of the specified units from total uricase subunits. At linkage of the given preparation with polyethylene oxide conjugates of an active uricase is obtained. The obtained conjugates of an active uricase are used in a pharmaceutical composition for depression of level of urinary acid in liquids and organism tissues.
EFFECT: invention application allows reducing immunogenic action of uricase, not decreasing its uricolytic action.
29 cl, 14 dwg, 18 ex
| Title |
Year |
Author |
Number |
| METHOD FOR ISOLATION OF TETRA-DIMENSIONAL FORM OF URICASE AND URICASE |
1999 |
- Villiamz L. Dehvid
- Khershfild Majkl S.
- Kelli S'Juzehn Dzh.
- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
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- Sajfer Mark Dzh. P.
- Shermehn Mehrri R.
|
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- Shermehn Merri R.
|
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|
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|
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|
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|
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2012 |
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|
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