METHOD FOR EVALUATING ANTICOAGULANT-FIBRINOLYTIC BLOOD POTENTIAL AT BURN DISEASE Russian patent published in 2005 - IPC

FIELD: medicine, diagnostics.

SUBSTANCE: the present innovation deals with blood sampling, separating plasma against erythrocytes, moreover, in plasma on should detect activity of antithrombin III, proteins C and S, XIIa-dependent fibrinolysis and concentration of plasminogen obtained results should be expressed as relative units followed by calculating integral parameter that characterizes the state of anticoagulant-fibrinolytic potential (IPAFP) by the following formula: IPAFP = [(C₁ + C₂)/(C₃ + C₄)] x 100, where C₁ - the ratio of observed value of antithrombin III activity to the value of inferior border of the range of analogous parameter norm; C₂ - the ratio of observed value for the activity of proteins C and S system to the value of inferior border of the range of this parameter norm; C₃ - the ratio of the value of inferior border of plasminogen concentration under normal conditions to observed value of analyzed parameter; C₄ - coefficient calculated with the help of regression equation: C₄ = 0.9 + (0.01 x X), where X - terms of lysis of patient's euglobulin clot/min, and at IPAFP value of 101.4 U and higher one should state anticoagulant-fibrinolytic blood potential to be in norm, in interval of 64.8 - 101.3 -as insufficient, and at 64.7 and below - as critical. The present method simplifies the procedure of evaluating the state of endogenous anticoagulants and activity of XIIa-dependent fibrinolysis.

EFFECT: increased diagnostic value of obtained results.

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