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2 268 881

(13)

(51)

IPC

C07C323/52(2006-01-01)

A61K31/194(2006-01-01)

A61P3/08(2006-01-01)

(21) (22)

Application

2001103136/04, 1999-07-02

(24)

Start date

1999-07-02

(22)

Actual filing date

1999-07-02

(45)

Published

2006-01-27

(72)

Inventor

Dzhekson Pol F.Maklin Kit M.Uang EhrikSlasher Barbara S.Lejpidus Rina S.Mejdzher Pavel

(73)

Holder

Gilford Farmas'Jutikalz Ink.

DERIVATIVES OF PENTADICARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS FOR TREATMENT Russian patent published in 2006 - IPC C07C323/52 A61K31/194 A61P3/08

Abstract RU 2268881 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of pentadicarboxylic acid of the general formula (I): or to their acceptable salts and solvates wherein X represents compound of the formula: wherein Z represents -SH; R₈ means -(CH₂)₂COOH; A means -CR₁₇R₁₈-; R₉ means hydrogen atom; R₁₀, R₁₁, R₁₇ and R₁₈ mean hydrogen atom, unsubstituted or substituted (C₁-C₉)-alkyl. Also, invention describes a pharmaceutical composition based on the claimed compounds. Compounds are designated for inhibition of enzymatic activity of enzyme NAALADase that provides the possibility for treatment of such diseases as ischemia, insult and schizophrenia by using these compounds.

EFFECT: valuable medicinal properties of compounds, improved treatment of diseases.

10 cl, 26 dwg, 7 tbl, 14 ex

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RU 2 268 881 C2

Authors

Dzhekson Pol F.

Maklin Kit M.

Uang Ehrik

Slasher Barbara S.

Lejpidus Rina S.

Mejdzher Pavel

Dates

2006-01-27—Published

1999-07-02—Filed