METHOD FOR PREDICTING REMOTE METASTASES AFTER RADICAL PROSTATECTOMY IN PROSTATE CARCINOMA PATIENTS Russian patent published in 2006 - IPC A61B10/00 A61B8/00 

FIELD: medicine.

SUBSTANCE: method involves determining preoperative factors like clinical stage of prostate neoplasm, prostate-specific antigen level, prostate capsule invasion with tumor from rectal finger palpation test data, prostate capsule invasion with tumor from transrectal ultrasonic examination data, the number of positive biopsy bars in carrying out transrectal prostate biopsy, neoplasm differentiation stage from transrectal ultrasonic examination, malignance degree from transrectal ultrasonic examination according to Glisson scale. Histological examination results are evaluated after previously done transurethral prostate resection. Postoperative factors like pathological neoplasm development stage, malignance degree from morphologic examination data according to Glisson scale and prostate tumor invasion into seminal vesicles from morphologic examination data are also determined. Remote metastasis index is calculated from formula M=0.24xT - 0.010xP + 0.87xR + 0.02xC + 0.15xB - 1.12xD + 0.07xKG + 0.38xH - 0.38xpT + 0.11xPG + 2.02xV, where M is the remote metastasis index, T is the clinical prostate neoplasm stage: 1 - T1; 2 - T2; 3 - T3; P is the prostate-specific antigen level before operation in ng/ml; R is the prostate capsule invasion with tumor according to rectal finger palpation test data: 0 - no invasion; 1 invasion available; C is the prostate capsule invasion with tumor according to transrectal ultrasonic examination data: 0 - no invasion; 1 invasion available; B is the number of positive biopsy bars in carrying out transrectal prostate biopsy: 1-6; D is the neoplasm differentiation stage from transrectal prostate biopsy: 1 low level differentiation degree;2 - moderate level differentiation degree; 3 - high level differentiation degree; KG is the malignance degree according to transrectal prostate biopsy data using Glisson scale 2-10; H is the histological examination after previously done transurethral prostate resection: 0 - not applied; 1 - benign prostate hyperplasia; 2 - prostate adenocarcinoma; pT is the pathological neoplasm development stage: 1 - pT2a; 2 - pT2b; 3 - pT3a; 4 - pT3b; PG is the malignance degree from morphologic examination data according to Glisson scale: 2-10; V is the prostate tumor invasion into seminal vesicles from morphologic examination data: 0 - no invasion; 1 invasion available; and if M>-1.55, remote metastasis formation is predicted.

EFFECT: high accuracy of prognosis.

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