METHOD FOR PREPARING QUINOLINE DERIVATIVES Russian patent published in 2007 - IPC C07D215/56 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of derivatives of quinoline. Invention describes a method for synthesis of compounds of the general formula (I): , wherein R is chosen from methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec.-butyl and allyl; R₅ is chosen from methyl, ethyl, n-propyl, isopropyl, methoxy-, ethoxy-, methylthio-, ethylthio-, n-propylthio-group, methylsulfinyl, ethylsulfinyl, fluorine, chlorine, bromine atoms, trifluoromethyl and -OCH_xF_y wherein x = 0-2; y = 1-3 under condition that x + y = 3; R₆ represents hydrogen atom; or R₅ and R₆ form in common methylenedioxy-group; R' is chosen from hydrogen atom, methyl, methoxy-group, fluorine, chlorine, bromine atoms, trifluoromethyl and -OCH_xF_y wherein x = 0-2; y = 1-3 under condition that x + y = 3; R'' is chosen from hydrogen, fluorine and chlorine atoms under condition that R'' is chosen from fluorine and chlorine atoms if R' is chosen from fluorine and chlorine atoms. Method involves carrying out interaction of quinoline-3-carboxylic acid ester derivative of the formula (A) with aniline derivative of the formula (B) in the following reaction: in a solvent medium chosen from normal or branched alkanes and cycloalkanes, or their mixtures with boiling point in the range 80-200°C. Invention provides simplifying method of synthesis of the end compound, enhancing yield and chemical purity of the end substance.

EFFECT: improved method of synthesis.

7 cl, 1 tbl, 3 ex