DERIVATIVES OF QUINOLINE, METHOD FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT WITH THEIR USING Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention describes derivatives of quinoline of the general formula (I) wherein R is taken among methyl, ethyl, n-propyl, isopropyl, n-butyl; R′ is taken among methyl, methoxy-group, fluorine, bromine, chlorine atoms, trifluoromethyl group and OCHxFy wherein x = 0-2; y = 1-3 under condition that x + y = 3; R″ is taken among hydrogen, fluorine and chlorine atoms under condition that R'' is fluorine or chlorine atom only when R' is taken among fluorine and chlorine atom; R₄ is taken among hydrogen atom or pharmaceutically acceptable inorganic or organic cations; R₅ is taken among ethyl, n-propyl, isopropyl, methoxy-group, ethoxy-group, chlorine, bromine atoms, trifluoromethyl group, OCH_xF_y or OCH₂CH_xF_y wherein x = 0-2; y = 1-3 under condition that x + y = 3; R₆ is hydrogen atom and R₅ and R₆ mean in common methylenedioxy-group and any its tautomer also. Invention describes also pharmaceutical composition eliciting anti-immune and anti-inflammatory effect containing compound of the general formula (I) in common with pharmaceutically acceptable carrier, methods for preparing compound of the formula (I) and to method of treatment mammals suffering with diseases caused by autoimmunity and pathological inflammation by administration of compound of the formula (I) to indicated mammal. Invention provides preparing compounds of the formula (I) eliciting anti-autoimmune and anti- -inflammatory effect. EFFECT: improved preparing method, valuable medicinal properties of compounds. 43 c, 2 tbl, 8 ex