DERIVATIVES OF QUINOLINE, METHOD FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT WITH THEIR USING Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention describes derivatives of quinoline of the formula (I) wherein R means methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec.-butyl; R' means hydrogen atom, methyl, methoxy-group, fluorine, chlorine, bromine atoms, CF₃ or OCH_xF_y; R'' means hydrogen or fluorine atom under condition that R'' means fluorine when R' means fluorine atom also and when R' and R'' are both hydrogen atoms then R is not methyl group; R₄ means hydrogen atom, or pharmaceutically acceptable inorganic or organic cation; R₅ means MeS, EtS, n-PrS, iso-PrS, MeSO, EtSO being x = 0-2; y = 1-3 under condition that x + y = 3; Me means methyl; Et means ethyl, Pr means propyl and Bu means butyl and any tautomers, optical isomers and racemates of these compounds also. Invention describes also pharmaceutical composition eliciting anti-auotoimmune and anti-inflammatory effect containing compounds of the general formula (I) in common with pharmaceutically acceptable carrier, to methods for preparing compounds of the formula (I) and to methods of treatment of mammals suffering with autoimmunity and pathological inflammation by administration of compound of the formula (I) to mammal. Invention provides preparing compounds of the formula (I) eliciting anti-autoimmune and anti-inflammatory effects that can be used for treatment diseases caused by autoimmunity and pathological inflammation. EFFECT: improved preparing method, valuable medicinal properties of compounds. 35 cl, 1 tbl, 4 ex