FIELD: synthesis of biologically active compounds.
SUBSTANCE: invention provides novel compounds of general formula I: 
(I), in which R1, R2, independently from each other, represent H, OH, OR5, or Hal; R3, R3', independently from each other, represent H or Hal; R4 represents CN or group 
; R5 is A or cycloalkyl having 3 to 6 carbon atoms optionally substituted by 1-5 F and/or Cl atoms, or -(CH2)-Ar group; A represents C1-C10-alkyl optionally substituted by 1-5 F and/or Cl atoms; Ar is phenyl; n = 0, 1 or 2; Hal is F, Cl, Be, or I; and pharmaceutically acceptable derivatives thereof, solvates, and stereoisomers, including their mixtures in any proportions. Invention also relates to a method of preparing compounds I, pharmaceutical agent manifesting inhibitory activity relative to phosphodiesterase IV, application areas, and intermediate compounds of formula I-I.
EFFECT: expanded synthetic possibilities in novel biologically active compounds areas.
14 cl, 4 tbl, 19 ex
