METHOD FOR PRODUCTION OF NANOCOLLOID FOR PRODUCING OF RADIOPHARMACEUTICAL AGENTS Russian patent published in 2008 - IPC A61K51/12 

FIELD: pharmaceutical chemistry, radioactive nuclide diagnosis and therapy.

SUBSTANCE: claimed method includes sequential mixing under cooling solutions of sodium perrhenate, gelatin, sodium thiosulfate, and hydrochloric acid at sodium thiosulfate and sodium perrhenate molar ratio of 1.5-3.4. Obtained mixture is heated on boiling water bath under continuous stirring for 10 min, cooled, conditioned for 2-3 h, passed through chromatography column filled with anion exchange resin and containing sterilizing filter. Filtrate is collected up to acidic fraction breakthrough, pre-packed at aseptic conditions into sterile bottles for drugs and stored in refrigerator. Said nanocolloid has 80 % or more particles with size of 2-100 nm; 5 % or less particles with size of <20 nm; nanocolloid solution has storage stability of 6 months or more; radioactive preparation obtained on the base of such nanocolloid has radiochemical purity of 90 % or more wherein said radiochemical purity is kept for not less than 4 hours.

EFFECT: new radiopharmaceutical agents useful in lymphoscintigraphy.

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