METHOD OF PRODUCING TECHNETIUM-99m LABELLED NANOCOLLOID Russian patent published in 2012 - IPC A61K51/02 A61K51/12 A61K103/10 B82B3/00 B82Y5/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing radioactive technetium-99m labelled nanocolloid. The method is characterised by adding a technetium-99m eluate to an aqueous suspension prepared from nanosized gamma-aluminium oxide powder with particle size of 7-10 nm and concentration of 0.5-0.7 mg/ml after bringing the pH of the medium to 4-5, followed by successive addition of ascorbic acid, tin (II) chloride dihydrate and gelatine in defined amounts. The obtained mixture is heated in a water bath at temperature 70-80°C for 30 minutes, cooled to room temperature in an ultrasonic bath and then subjected to sterilisation filtration.

EFFECT: invention enables to obtain ^99mTc-Al₂O₃ nanocolloid, used based on its size to conduct diagnostic research for which not less than 80% of the particles have size in the range of 20-100 nm, and the radiochemical purity of the preparation is higher than 90%.

1 dwg, 2 tbl, 3 ex