METHOD FOR PREPARING 1-HEXADECYL-R-(-)-3-HYDROXY-1-AZONIABICYCLO[2.2.2]OCTANE BROMIDE - IMMUNOMODULATOR ELICITING ANTITUMOR, BACTERIOSTATIC AND ANTI-AGGREGATIVE PROPERTIES Russian patent published in 2008 - IPC C07D453/02 A61K31/439 A61P37/02 A61K31/14 

Abstract RU 2321589 C2

FIELD: organic chemistry, medicine, chemical technology.

SUBSTANCE: invention describes a method for synthesis of 1-hexadecyl-R-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane bromide represented by the formula: . Method involves interaction of 1-hexadecyl-R-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane with hydrobromic acid or its inorganic salt (for example, sodium bromide or potassium bromide) in water in the ionic exchange reaction. 1-Hexadecyl-R-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane bromide represents an immunotropic agent that shows versatile effect on human immune status and elicits antitumor, bacteriostatic and anti-aggregate effects. Invention proposes a method for synthesis of a novel synthetic low-molecular preparation possessing the expressed stimulating effect on the antitumor immunity system that is equal or exceeding by effectiveness effect of the modern domestic and foreign preparation - immunomodulators that represent natural high-molecular biologically active substances prepared by methods of genetic engineering.

EFFECT: improved method of synthesis, valuable medicinal and biological properties of substance.

1 cl, 6 tbl, 21 dwg, 4 ex

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RU 2 321 589 C2

Authors

Anikienko Konstantin Aleksandrovich

Pankov Dmitrij Igorevich

Polezina Alevtina Sergeevna

Mikhaleva Irina Leonidovna

Kiselevskij Mikhail Valentinovich

Anisimova Natal'Ja Jur'Evna

Donenko Fedor Vital'Evich

Dobrjanskij Vjacheslav Stanislavovich

Poljakov Viktor Stanislavovich

Mel'Nikov Vladimir Alekseevich

Petrunin Viktor Alekseevich

Baryshnikov Anatolij Jur'Evich

Dates

2008-04-10Published

2005-08-19Filed