FIELD: organic chemistry, medicine, chemical technology.
SUBSTANCE: invention describes a method for synthesis of 1-hexadecyl-R-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane bromide represented by the formula: . Method involves interaction of 1-hexadecyl-R-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane with hydrobromic acid or its inorganic salt (for example, sodium bromide or potassium bromide) in water in the ionic exchange reaction. 1-Hexadecyl-R-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane bromide represents an immunotropic agent that shows versatile effect on human immune status and elicits antitumor, bacteriostatic and anti-aggregate effects. Invention proposes a method for synthesis of a novel synthetic low-molecular preparation possessing the expressed stimulating effect on the antitumor immunity system that is equal or exceeding by effectiveness effect of the modern domestic and foreign preparation - immunomodulators that represent natural high-molecular biologically active substances prepared by methods of genetic engineering.
EFFECT: improved method of synthesis, valuable medicinal and biological properties of substance.
1 cl, 6 tbl, 21 dwg, 4 ex
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1-HEXADECYL-R-(-)-3-OXY-1-AZONIABICYCLO[2.2.2]OCTANE BROMIDE AS IMMUNOMODULATOR WITH ANTITUMOR, BACTERIOSTATIC AND ANTI-AGGREGATION PROPERTIES AND METHOD FOR ITS PREPARING | 2005 |
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Authors
Dates
2008-04-10—Published
2005-08-19—Filed