AZA-RING BRIDGED COMPOUND Russian patent published in 2012 - IPC C07D453/02 C07D471/18 A61K31/439 A61P29/00 

FIELD: pharmacology.

SUBSTANCE: invention refers to the compound of formula(I) or to is salt where R¹ is -H or C_1-6 alkyl; R² is bridged aza-ring chosen out of group including formula and where ring hydrogen atom in bridged aza-ring may be substituted by one or several groups of R²²; m, n and p have respective values 1 or 2; r has the value 0 or 1; R²¹ is C_1-6 alkyl, -C_1-6 alkyl-O-phenyl or -C_1-6 alkyl-phenyl; R²² is C_1-6 alkyl-cycloalkyl or -C_1-6 alkyl-phenyl; R² is thienyl, phenyl, pyridyl, pyranzinyl, thiazolyl or pyrazolyl, each of which can be substituted by one or several R³¹; R³¹ is the halogen, -OH, -CN, -CF₃, C_1-6 alkyl or -O-C_1-6 alkyl; ring A is the group consisting of thiophene, thiazole, isothiazole, thidiazole, oxazole, isooxazole, cyclohexan, norboran, benzothiophene and 5,6-dihydro-4H-cyclopentathiophene, each of which can be substituted by the group chosen out of the group consisting out of one or several R^A1; where R^A1 is a halogen, -CN, -NH₂, C_1-6 alkyl, -O-C_1-6 alkyl, CONH₂, - HN-C_1-6 alkyl, -HN-C_1-6 alkyl-O-C_1-6 alkyl-phenyl, -HN-C_1-6 alkyl-phenyl or -HN-C_1-6 alkyl-OH where C_1-6 alkyl can be substituted with one or several halogen atoms; V is -NH- or -O-; W is -(CH₂)_q-; q has the value 0.1 or 2; X is the counteranion and is an ordinary bond; on condition when in case ring A is cyclohexane, R³ is phenyl which can be replaced with one or several R³¹. The invention also refers to pharmaceutical composition that has antagonistic effect on muscarine receptor M3, on the basis of said compound.

EFFECT: production of new compound and pharmaceutical composition on its basis, which can be applied in the medicine as an active substance for preventive and/or therapeutic drug for treatment of inflammatory diseases such as chronic obstructive pulmonary disease (COPD), asthma and the like.

14 cl, 60 tbl, 15 ex