1-HEXADECYL-R-(-)-3-OXY-1-AZONIABICYCLO[2.2.2]OCTANE BROMIDE AS IMMUNOMODULATOR WITH ANTITUMOR, BACTERIOSTATIC AND ANTI-AGGREGATION PROPERTIES AND METHOD FOR ITS PREPARING Russian patent published in 2007 - IPC C07D453/02 A61K31/439 A61K31/14 A61P37/02 

Abstract RU 2296761 C2

FIELD: organic chemistry, medicine, pharmacology, pharmacy.

SUBSTANCE: invention relates to an agent eliciting immunomodulating, antitumor, bacteriostatic and anti-aggregation properties and representing 1-hexadecyl-R-(-)-3-oxy-1-azoniabicyclo[2.2.2]octane bromide and a method for its synthesis. Method involves quartenization of R-(-)-azabicyclo[2.2.2]octane-3-ol with hexadecyl bromide at heating in organic solvent medium. Agent shows low toxicity, high effectiveness, it doesn't cause allergic effect and doesn't possess cumulative effect.

EFFECT: valuable medicinal properties of agent.

3 cl, 9 dwg, 6 tbl, 2 ex

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RU 2 296 761 C2

Authors

Anikienko Konstantin Aleksandrovich

Pankov Dmitrij Igorevich

Polezina Alevtina Sergeevna

Mikhaleva Irina Leonidovna

Kiselevskij Mikhail Valentinovich

Anisimova Natal'Ja Jur'Evna

Donenko Fedor Vital'Evich

Dobrjanskij Vjacheslav Stanislavovich

Poljakov Viktor Stanislavovich

Mel'Nikov Vladimir Alekseevich

Petrunin Viktor Alekseevich

Baryshnikov Anatolij Jur'Evich

Dates

2007-04-10Published

2005-04-28Filed