FIELD: organic chemistry, biochemistry, medicine.
SUBSTANCE: invention relates to phosphoramidates of nucleoside analogs comprising 2',3'-dideoxy-2',3'-didehydrothymidine 5'-phosphodimorpholidate of the formula (I) 
and phosphoramidates of 3'-azido-3'-deoxythymidine of the formula (II) 
and the formula (III) 
that inhibit activity in reproduction of human immunodeficiency virus (HIV). Compounds are resistant to effect of dephosphorylating enzymes and able to penetrate into cells and elicit the selective activity in inhibition of DNA biosynthesis catalyzed by HIV-reverse transcriptase.
EFFECT: valuable medicinal and biochemical properties of nucleoside analogs.
4 dwg, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 5'-AMINOCARBONYLPHOSPHONATES D4T AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPRODUCTION | 2003 |
|
RU2247124C1 |
| 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE-5'-[(ETHOXY-CARBONYL)(ETHYL)PHOSPHONATE] AS INHIBITOR OF REPRODUCTION OF HUMAN IMMUNODEFICIENCY VIRUS | 2000 |
|
RU2188203C2 |
| MODIFIED 5'-PHOSPHONATES OF 3'-AZIDO-3'-DEOXYTHYMIDINE AS ACTIVE COMPONENTS FOR POTENTIAL ANTIVIRAL PREPARATIONS | 2004 |
|
RU2322450C2 |
| MODIFIED NUCLEOSIDE-5'-TRIPHOSPHATES AS ANTIVIRAL AGENTS | 1996 |
|
RU2183213C2 |
| 5'-PHOSPHORUS-CONTAINING DERIVATIVES OF 2',3'-DIDEOXY-3'-THIACYTIDINE - NEW ANTIVIRAL AGENTS | 2007 |
|
RU2373218C2 |
| 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-CHOLINE PHOSPHATE AS ANTIVIRAL AGENT | 2002 |
|
RU2293739C2 |
| URETHANE AZT DERIVATIVES - POTENTIAL ANTIVIRAL AGENTS | 2009 |
|
RU2430103C1 |
| NOVEL DEPOT-FORMS OF ZIDOVUDINE AND LAMIVUDINE BASED ON PHOSPHONIC ACID DERIVATIVES | 2009 |
|
RU2430104C1 |
| DERIVATIVES OF 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-H-PHOSPHONATE AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 2001 |
|
RU2187509C1 |
| 5'-AMINOCARBONYLPHOPHONATE 3'-AZIDO-3'-DEOXYTHYMIDINE SALTS BEING SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS HIV-1 | 2010 |
|
RU2441016C1 |
