PHARMACEUTICAL COMPOSITION FOR PHOTODYNAMIC TREATMENT AND METHOD OF TREATMENT OF ONCOLOGY DISEASES WITH USE OF COMPOSITION Russian patent published in 2008 - IPC A61K31/195 A61K38/05 A61P35/00 

Abstract RU 2323722 C2

FIELD: medicine, oncology.

SUBSTANCE: invention is related to pharmaceutical composition for photodynamic treatment of malignant tumors, which contains therapeutically efficient amount of at least one of fullerene С60 derivatives from group of compounds, which have fullerene С60 molecule that is bound with one molecule of amino acid or dipeptide, or its pharmaceutically acceptable derivative, or complex of association with biocompatible synthetic polymers or biolpoimers and tetra pyrroles, or conjugate of association with amino compounds. Patented composition which includes the above mentioned compounds, allows using emission spectrum up to 1 mcm for photodynamic treatment, which in turn, enables broadening the application area of photodynamic treatment due to penetration of light with such wave length into deep tissues. The invention also relates to the method of photodynamic treatment of malignant tumors, when the patented pharmaceutical composition is applied.

EFFECT: composition has low toxicity and high accumulation selectivity in tumor tissues.

7 cl, 7 ex, 12 dwg

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Authors

Andreev Sergej Mikhajlovich

Laptev Vladimir Petrovich

Panferova Natella Georgievna

Romanova Valentina Semenovna

Petrov Valentin Viktorovich

Ovchinnikov Aleksandr Evgen'Evich

Dates

2008-05-10Published

2005-12-26Filed